and Ma Huang
has been written and spoken about Ma Huang (Ephedrine) lately,
and some concerns have been raised regarding its use as a dietary
supplement. Unfortunately, as Dr. Zoltan P. Rona, a practicing
medical doctor in Toronto, Canada, has noted, "much of the information
being released on Ma Huang is misleading."
While TSN Labs, Inc. sees it as a positive sign that people
are taking an interest in the safety of the supplements they
use, we feel it is extremely important that these people have
available to them accurate and credible information upon which
to base their judgements. For this reason, the following information
is provided with the intent of educating supplement users as
to the background and current situation surrounding the use
of one of nature's oldest medicines. Simply put --- Don't believe
the hype..... Educate yourself!!!!
For more information on one of the Safest, Simplest and most
Effective natural weight loss Ma Huang products available, check
out Thin & Slim Naturally.
Choose from the following categories, or scroll down through
Huang is known as one of the world's oldest medicines. Ma
Huang (also known as Ephedra herb) is a member of the family
of herbs known as the Ephedraceae. It has been used in China
for more than 5,000 years to treat symptoms of asthma and
upper respiratory infections. Related varieties of the herb
are also grown in India, Europe, Australia, and Afghanistan.
American ephedra, native to the dry southwest, was used
as a tea by the area's native people and introduced to early
American settlers, who called it "Mormon Tea." It has also
been used in the treatment of headaches, fevers, colds,
and hay fever. Today, compounds derived from this herb are
commonly found in many over-the-counter (OTC) cold and allergy
medications. Ma Huang is also found in some weight loss
and energy products. For dieters, it suppresses the appetite
and stimulates metabolism through a process known as thermogenesis.
Recently, Ma Huang has been the subject of scientific research
for obesity because of this thermogenic fat-burning effect.
The Current Situation
enacted the Dietary Supplement Health & Education Act
(DSHEA) to protect consumers and prevent the arbitrary regulation
of herbal dietary supplements. DSHEA provides that herbal
supplements may be restricted only when a product poses
an imminent hazard to the public health when consumed at
its labeled servings. Nevertheless, the Food and Drug
Administration (FDA) and several states are now considering
violating DSHEA, by taking severe regulatory action that
would remove ephedra herb dietary supplements from the market,
or so restrict their content and labeling as to effectively
preclude their use. These drastic actions purposefully ignore
the wide body of scientific literature, several dozen clinical
trials in humans, extensive animal studies, and recent reviews
by expert toxicologists, all showing that ephedra herb products
are safe when used as directed. Indeed, while the FDA is
considering limiting these products to less than 10 mg per
serving four times a day, the FDA's own drug regulations
provide for safe use of ephedrine at 25 mg six times a day,
and there are no indications of injuries from that dose.
Medical science says ephedra herb products are safe
and effective when used as directed in helping you lose
weight and increase your energy level. But FDA politics
may deprive you of your right to distribute, purchase and
use safe ephedra herb dietary supplements. Let the FDA and
your elected officials know that you value your rights and
oppose arbitrary restrictions on the sale and purchase of
ephedra herb products. You can write the FDA at:
David A. Kessler
of Food and Drugs
Building, Room 1471
Science or Political Myth?
study found that in the most overweight individuals,
the combination of ephedrine + caffeine(EC) was
29% more effective than dexfenfluramine. Another
study found that when compared to losing weight
by diet alone, EC had a positive influence on body
composition, increasing fat loss by 100% and decreasing
muscle loss by 72%." Townsend
Letter for Doctors & Patients - June 1996
||During the Food Advisory
Committee's recent hearings in Washington, D.C.,
the FDA attempted to discourage speakers and members
of the committee from discussing the benefits of
ephedra as an agent to aid in weight loss.
|"None of the literature
reports support the contention that ephedrine in
reasonable dosage would represent a hazard to health...
In the formal study, 100 subjects received...Ma
Huang at an average dose of 5 tablets [23 mg/tablet]
per day for 8 weeks. No side effects of any kind
were reported, no changes in blood pressure were
seen, rates of weight loss improved..." Safety
of Ephedra Herb: A Preliminary Report.
||The FDA's allegations
of risk are not supported by scientific or empirical
data. The FDA has not cited a single article to
support its conclusions, nor has it made any attempt
to rebut the studies and over 200 articles from
scientific literature supporting the safety of ephedra
herb which have been submitted..
have been more than 20 significant publications
in prestigious scientific journals, describing the
effects of ephedrine in doses of 60-150 mg per day
for periods of up to 26 months... Ephedrine...did
not cause increases in blood pressure or heart rate...There
were no clinically important side effects in the
reviewed studies..." Ad Hoc Committee On the
Safety of Ma Huang - June 1995.
||FDA is considering a
serving limitation of 2-10 mg without having any
studies suggesting that larger servings are unsafe
and contrary to its own OTC Regulations.
|"25 mg up to six times
per day." FDA's Over-The-Counter Drug Regulations.
|"The drug ephedrine...poses
little risk when compared to common household products
such as aspirin, ibuprofen, acetaminophen, sleep
aids and caffeine." Ad Hoc
Committee On the Safety of Ma Huang- September 1996.
||There are only about
36 reports available to the FDA in which it can
even be determined what amount of ephedra was claimed
to have been consumed by the reporting individual.
|The Committee on Safety
of Medicine in the United Kingdom recently acknowledged
that it had only received 22 reports of adverse
reactions associated with ephedrine drug weight
loss products over a multi-year period. Recent Danish
data on an ephedrine-caffeine combination for weight
loss indicated only 86 reportable adverse reactions
over a two-year period from 9.6 million reported
25 mg servings.
||Even the FDA concedes
that most cases are complex, with patient factors
that make interpretation of individual events problematic.
Moreover, these reports come from a population of
at least 8 million Americans who consume over 1
billion servings of ephedra herb products each year.
|"A retrospective study
of 230,000 subjects, who over a three-year period
had used ephedra herb supplements at single servings
of about 20 mg/3-5 times per day, for periods of
six to eleven weeks, revealed no serious adverse
effects, including no increases in blood pressure
and no increases in heart rates." Ad
Hoc Comm. on the Safety of Ma Huang- Sept. 1996
||FDA has received only
602 unverified and unevaluated reports,
many of which have been subsequently proven to be
erroneous, unrelated or involve consumption at extreme
literature reviews, clinical testing, animal studies,
known toxicology, absence of injuries in over-seas
or other defined populations, and the safe use of
ephedra herb products at 25 mg doses without adverse
incidents all demonstrate that ephedra herb dietary
supplements are unlikely to pose a risk of injury
at labeled servings, a fact confirmed by thousands
of years of use. Given this scientific background,
any reported injuries should be scrutinized with
great care, because such reports are at odds with
all that is known about these products' safety."Ad
Hoc Comm.on the Safety of Ma Huang -Sept. 1996.
||The FDA treats all alleged
complaints as valid, regardless of whether an actual
injury occurred. For instance:
-Several reports failed to state
-Dozens of cases were included where
the patient was taking multiple prescription drugs
with known side effects and such side effects
were erroneously attributed to ephedra
toxicologists reviewed the reports collected by
the FDA and the Texas Dept. of Health. Their response
was that "it is impossible to establish any causal
relationship between ingestion of these products
and any serious adverse effect...It is our opinion
that at the labeled doses...there is virtually no
basis, in these materials or the literature, to
conclude [that these products] would cause any serious
adverse effect in human beings." Ad
Hoc Comm. on the Safety of Ma Huang -Sept '96
||-Several reports came
from unidentified "friends" who alleged bad experiences
without any detail
-Several claims counted by the FDA
concerned products containing no ephedrine. Even
more alarming is that the FDA was advised of this
fact in 1995 yet continued to include them.
the above table demonstrates the safety of the drug ephedrine,
it should be noted that many scientists and herbalists argue
that use of the herb in whole plant form (Ma Huang) is even
safer than the refined derivative (pure ephedrine &
psuedoephedrine). In fact, studies show that the whole herb
Ma Huang has a very low toxicity and little potential for
side effects (Tang & Eisenbrand, 1992), and animal studies
have failed to demonstrate carcinogenic or mutagenic potential
for ephedrine. Further, ephedrine is rapidly eliminated
from the human body -- 88% of an oral dose is excreted in
the urine within 24 hours, 97% after 48 hours (Hobbs, 1996).
In Herbal Medicine for Everyone, British herbalist
Michael McIntyre writes that while pure ephedrine may raise
blood pressure, the "whole (ephedra) plant actually reduces
blood pressure." German medical herbalist Rudolph Fritz
Weiss, M.D., maintains that the whole plant "has certain
advantages (over psuedoephedrine). Above all, it is better
tolerated, causing fewer...symptoms." Finally, practitioners
of Traditional Chinese Medicine (TCM) would regularly prescribe
Ma Huang with other tonic herbs to improve safe consumption.
This theory is maintained by TSN Labs, Inc. Our product,
& Slim Naturally,
was formulated by Mr. Steve Lee, a native of Taiwan. He
is a graduate of Duquesne University of Pharmacy in Pennsylvania,
with a Masters Degree in Industrial Pharmaceutics. Steve
Lee's professional experience in pharmaceutical chemistry
has been extensive and diverse, including Laboratory Manager
at the U.S. National Institute of Health. He has been instrumental
in the formulation of a wide variety of health and nutritional
products for as many as eight different companies. Mr. Lee
has served on the FDA Advisory Committee for Herbal Medicines.
Steve Lee brings to TSN Labs, Inc., a thorough understanding
of pharmaceuticals and western medical practices, as well
as a deep background in herbal medicines, whose safety and
effectiveness have been proven in China and the rest of
Asia for more than 5000 years. It is through this diverse
knowledge of both the Oriental and Occidental worlds, that
Mr. Lee has been able to formulate one of the safest and
most effective natural dietary supplements on the market
today. That product is Thin
& Slim Naturally.
American Medical Association. Drug
Evaluations. Chicago: American Medical Assoc. 1986.
Barnhart, E. (pub.) Physicians'
Desk Reference. Oradell, NJ: Medical Economics Co.,
Bensky, D. and A. Gamble. Chinese
Herbal Medicine. Seattle: Eastland Press. 1986.
Chang, H.M. Pharmacology and
Applications of Chinese Materia Medica. Philadelphia:
World Scientific. 1986.
German Commission E Monograph, Ephedra
herba, published January 17, 1991.
Hsu, H.Y. (pub.). Oriental Materia
Medica. Long Beach: Oriental Healing Arts Institute.
Huang, K.C. The Pharmacology
of Chinese Herbs. Boca Raton: CRC Press. 1993.
Tang, W. & G. Eisenbrand. Chinese
Drugs of Plant Origin. Berlin: Springer-Verlag. 1992.
statements herein have not been evaluated by the FDA,
and are intended for educational purposes only. These
products are not intended to treat, diagnose, cure , mitigate
or prevent any disease. If you have a serious medical
condition, consult with your doctor before using.